What is salicylate and what are its uses?

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Aspirin-related choline salicylate is an anti-inflammatory pain reliever. It is used to relieve mild to moderate pain and to reduce edoema. Adults and children can both use it to treat arthritis. Fever can also be treated with this medication. 

Salicylic acid’s choline salt, choline salicylate, is a painkiller, antipyretic, and antirheumatic. It lessens fever, mild to severe discomfort, inflammation, and edoema. Treatment of gout, rheumatic fever, rheumatoid arthritis, and muscle injuries with choline salicylate is successful.

This medication is also a key component of teething gels used to treat infants’ teething discomfort. Its use is restricted in the UK since it can be hazardous for children under the age of 16. Topical oral salicylate gels are no longer advised for use by those under the age of 16 for discomfort brought on by cold sores, mouth ulcers, orthodontic devices, or teething in infants 13.

Choline salicylate decreases temperature by acting on the hypothalamus’ heat-regulating region and alleviates pain by preventing the creation of prostaglandins. Through the suppression of the COX-11 enzyme, it also prevents the creation of impulses. 

In reaction to injury and following a variety of other stimuli, cyclooxygenase is involved in the generation of prostaglandins. Inflammation, swelling, and discomfort are all caused by prostaglandins. By lowering the synthesis of these prostaglandins in the area of the mouth where it is administered, choline salicylate lessens swelling and discomfort.

Plasma values of >350 mg/L (2.5 mmol/L) of salicylate are typically linked to poisoning. Patients whose serum salicylate concentrations are over 700 mg/L (5.1 mmol/L) are most likely to die from salicylate poisoning in adults. Serious poisoning from a single dose of less than 100 mg/kg is exceedingly uncommon. If necessary, patients should get supportive therapy or treatment for salicylate toxicity. This might involve therapy like hemodialysis, urinary alkalinization, or activated charcoal.